Fragments 2009

The aim of the 2^nd RSC – BMCS Fragment-Based Drug Discovery meeting will be to continue the focus on Case Studies in Fragment-Based Drug Discovery that have delivered compounds to late stage medicinal chemistry, preclinical or clinical programs.  These case studies will include successful examples from all types of Fragment-Based approaches, including High concentration, NMR, SPR and X-ray screening.  This conference is suitable for scientists from any discipline with an interest in expanding their knowledge and experience of FBDD.

Programme

Wednesday 4 March

09.30   Registration & Coffee

10.20   Opening Remarks
            Andrew Mortlock (VP for Oncology, AstraZeneca, UK)

10.30   Thinking small: Biophysical approaches to fragment-based drug discovery
            Glyn Williams (Astex Therapeutics, UK)

11.15   Fragment-based lead generation: Experiences and challenges
            Samantha Hughes (Pfizer, UK)

12.00   Short oral presentation

12.20   Lunch and Poster Session

13.45   From leads to fragments and back again: Fragment-based design of DNA gyrase inhibitors
            Alex Breeze (AstraZeneca, UK)

14.30   Target immobilization provides new opportunities in NMR-based fragment discovery and characterization
            Gregg Siegal (ZoBio, The Netherlands)

15.15   Coffee

15.45   Fragments of life targeting infectious disease
            Lance Stewart (DeCode, USA)

16.30   Design intensive fragment-based drug discovery
            Iwan de Esch (VU University Amsterdam, The Netherlands) 

Thursday 5 March 2009

09.00   Title to be announced
            Bob McDowell (formerly SunesisUSA) 

09.45   Fragment-based lead discovery in CNS diseases
            Vicki Nienaber (President and CSO Zenobia Therapeutics, Inc., USA)

10.30   Coffee 

11.00   Harnessing fragments in big pharma: Examples and processes at GlaxoSmithKline
            Nino Campobasso (GlaxoSmithKline, USA)

11.45   Fragment screening on human chymase by BIAcore and X-ray
            David Banner (F Hoffmann-La Roche, Switzerland) 

12.30   Lunch and Posters 

13.30   Maximising information from fragments through the combination of biochemical and NMR screening
            Mark Whittaker (Evotec, UK)

14.15   Fragment based hit discovery in parasitic diseases
            Paul Wyatt (University of Dundee, UK)

15.00   I see fragments everywhere - from drug analysis to design
            Michal Vieth (Lilly, USA)

Call for Posters

Posters are seen as an important part of the meeting and will be displayed throughout.  Poster sessions will take place each lunchtime.  Offers of posters relevant to the themes of the meeting are invited.  Please submit a one-page abstract in Word, 12 pt Ariel font, to reach the Secretariat by 5 January 2009.

Further information

The final circular contains the full programme with details of accommodation options, social events and travel advice, fees, bursaries and application form.

Please click here for a pdf of the FINAL CIRCULAR