Lessons Learned in Medicinal Chemistry
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But
Mousie, thou are no thy-lane,
In proving foresight may be vain:
The best laid schemes o' Mice an' Men,
Gang aft agley,
An' lea'e us nought but grief an' pain,
For promis'd joy!
From
"To A Mouse, on Turning Her Up in Her Nest, With The Plough” (1785)
Robert Burns (1759- 1796)
In the main there are two types of drug discovery projects: those that hit serious problems and those that are going to hit serious problems. The difference between success and failure is how we, as medicinal chemists, tackle and resolve these problems.
On a technology front we shall hear about the latest concepts in ADMET, Informatics and CADD. The speakers have also been asked to tell their medicinal chemistry worked examples as they happened, highlighting the problems encountered and their eventual solutions.
This meeting is aimed at all those medicinal chemists who want to become better drug hunters.
Programme
09.00 Drug Discovery Technologies – A Closer Look
Hugo Kubinyi
09.45 Learning
from the Structure-Based Design of Inhaled PDE4 Inhibitors
John Mathias (Pfizer)
10.30 Coffee break
10.55 Incorporating ADMET into Drug Design, promises and
pitfalls
Dennis Smith (Pfizer)
11.40
Creation of UK-453061. A Novel Non-Nucleoside Reverse
Transcriptase Inhibitor for the
Treatment of HIV
Charles Mowbray (Pfizer)
12.25
The Protein Factor: From Structure-Based Drug Design to
Describing Chemotypes
Jonathan Mason (Lundbeck Research)
13.10 Lunch
13.55 The Discovery of Novel CB1 Antagonists
Phillip Cowley (Schering-Plough)
14.35 Cheminformatics
Paul Leeson (AstraZeneca)
15.15 Tea
15.40 The
Discovery of Sugammadex at Organon
Ming Zhang (Biotica)
16.20 Discovery and Structure Gided Optimaisation of Hsp90
Inhibitors for the treatment of cancer
Martin Drysdale (Vernalis)
Further information
Full details are available in the circular and application form. Please click here for a pdf version.